Constant & Variable Region & Their Relation in Immunoglobin Molecule Questions

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1. Define the terms constant region, variable region and explain how they relate to an immunoglobulin molecule. (2 points)

2. How is the immune system able to generate very diverse amounts of B and T lymphocytes with unique receptors? (5 points)

3. Describe in detail the organization of the Ig gene loci. (10 points)

4. Explain how the collection of enzymes called the V(D)J recombinase mediates the somatic recombination of V and J (or V, D, and J) gene segments. (5 points)

5. Discuss the two types of sequence changes that produce junctional diversity. (5 points)

6. Explain in detail how heavy chain class switching is initiated, and what happens to IgM-producing B cells that have not undergone switching. (6 points).

7. Explain how the molecular mechanism of affinity became defined? (3 points)

8. What are memory cells and why are they important to the human immune system? (4 points)

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