Respond to the post (Talk about the intolerance piece of metformin such as the GI side effects etc)
Metformin for Treatment of Type 2 Diabetes
Metformin is part of the first treatment step in the four-step treatment approach. Metformin works in several different ways to manage blood glucose levels. One way is inhibiting glucose from being produced in the liver. Another way is that it slightly reduces glucose from being absorbed in the digestive tract. It also increases glucose uptake in tissues such as fat and skeletal muscle by increasing the sensitivity of insulin receptors.
One of the positives of treatment with metformin is that there are few side effects, and because it does not actively reduce blood sugar, there is hardly any risk of hypoglycemia. The most common side effect is gastrointestinal issues. Although it is not common, the severe side effect is metabolic acidosis and is mainly a concern in patients with impaired renal function.
Metformin is prepared as an oral medication; either an immediate-release or extended-release tablet or an oral solution is available. Metformin should be taken with food to avoid gastrointestinal upset side effects (Corcoran & Jacobs, 2022).