Alnylam Pharmaceuticals Case Study

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The Alnylam Pharmaceuticals Case Study describes a commercialization scenario in which Alnylam has filed a lawsuit against the co-owners of a patent pending application. In addition, to addressing the validity of patent(s) pending, the case illustrates the importance of the outcome of the aforementioned litigation on the Company’s corporate strategy. As with the previous case write-up assignments the questions for this Case Study write-up require you to explain critical aspects of the case from a situational perspective, as well as to develop replies to specific questions presented by the case.

Case Study Write-Up Questions

1. In 2-3 paragraphs please present a situational description of the case that addresses: Who is Dr. John Maraganore? Who are the stakeholders involved in the case and what are their roles? Why are they working (or not working) together collaboratively?

2. How do you balance the risks vs. rewards of Alnylam’s licensing strategy? What are its pros and cons? How should Alnylam sustain its IP and licensing strategy? Should Alnylam Pharmaceuticals convert its business model such that it becomes an intellectual property licensing company?

3. Are there specific aspects about RNA interference as a technology platform that

make it easier or harder to develop and subsequently execute an intellectual property strategy to protect it?

4. Why are the co-owners of the Tuschl I patent arguing over the patent’s prosecution?

5. If Merck, through Sirna, has a license to Tuschl I, should it also need a license from Alnylam?

6. At what point, if ever, should Alnylam negotiate with Merck for a license to the latter’s intellectual property

In addressing the questions presented, please feel free to develop and utilize diagrams to support your answers

Intersection of Ethics and Policy

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Consider the following scenarios:

Scenario 1: One of the physicians on staff is telling you about a study that he is doing on his patients. He hopes to have the study published and to receive a grant to expand his research. He offers to hire you to help him with the data collection during your off hours. You accept and begin helping him. You start collecting data. When you access the file the next day, you realize that he has removed a number of patients from the study. You suspect that they were removed intentionally, but you cannot be sure.

You put your suspicions aside and proceed with your work and add more patients to the database. A few days later, more patients have been removed from the database. When you do some investigation, you discover that the patients who were removed were sicker and/or had a poor outcome. This is a problem and may prevent the rewarding of the grant money to this project.

Scenario 2: You are traveling with your work laptop to a conference and leave it for five minutes at the airport terminal as you go to the bathroom. You asked your colleague to keep an eye on it, but when you return, your colleague has boarded the plane and taken your belongings. As you look through, you realize your laptop is missing. When you confront your colleague, she says it was just there a moment ago and she is certain she brought it on board with her. Your laptop contains secure information regarding your organization and has remote access to your clinical information system. The policy at your organization for a data breach is to call tech support immediately and report the breach. You think it may just be misplaced and begin looking.

 

Choose one of the scenarios above and answer the following:

  • What challenges are present in the scenario, and what are some steps that can be taken to address them?
  • What is the relationship between ethics and policy? Do they always match up with one another?
  • If individual ethics do not align with organizational policy, what might be the end result?

Support your answer with relevant resources.

High Increase in The Number of Chronic Diseases

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Your scholarly voice is also your professional voice and it may change depending on your audience. As a health professional you will engage in issues and topics of interest with various colleagues. How you communicate with these colleagues will differ depending upon the nature and purpose of the interaction.

For this Assignment, envision yourself as a future leader in the health field. Consider how you would introduce to different audiences the issue you selected in Week 1.

The Assignment (3 pages)

Select one scenario from the list below.

Note: You will introduce the same issue you selected in Week 1 to complete the assignment.
An introduction to an academic journal article

Note: You will introduce the same issue you selected in Week 1 to complete the assignment.

Public health is critical in the community and in determining how people live in the community. One of the issues that I am interested in is people’s lifestyles. Lifestyle is very critical in determining people’s health in terms of immunity and also obesity issues. Obesity is a leading cause of deaths in the United States (Greenberg, 2013). Lifestyle involves how people exercise in the community and their way of feeding. I am mainly concerned due to the increased obesity in the community, and there is a need to address the lifestyle to reduce chronic diseases.

I am motivated to ensure that people live healthy lives while taking the best diet that is beneficial to their health. Statistics indicate that obesity is one of the growing health issues in the United States and catalyzes chronic diseases. Lifestyle is an issue related to public health because it determines the health in the community. I am specifically targeting to ensure people are in a position to live healthy in the community for my assigned community. It will help to promote population-focused health that focuses on the community as a whole.

References

Greenberg, J. A. (2013). Obesity and early mortality in the United States. Obesity, 21(2), 405-412. doi:10.1002/oby.20023

Zimmerman, D. L. (n.d.). Overview and framework of person-focused health care management. Person-Focused Health Care Management. doi:10.1891/9780826194367.0001

A written memo to the employees at work
Letter to community agency, organization, or key stakeholder in the issue

Using your scholarly voice, introduce an issue or topic in your health field and write what you would say.

Note: Expand on your insights utilizing the Learning Resources.

program leadership

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Bottom of Form

Points: 30 | Due Date: Week 8, Day 7 | CLO: 4 | Grade Category: Assignments

In week 7 or 8, FNP program leadership or senior faculty will give a live or recorded lecture on upcoming course requirements, including an introduction to the “Three Ps” (Pathophysiology, Pharmacology, and Physical Assessment). And the clinical course expectations. Students should attend the lecture live if possible (which affords them a chance to participate and ask questions) or alternatively. The student may watch the recording. The dates and times as well as zoom link and recording will be posted in this document:  LINK

If the link above does not work, copy and paste this URL into your browser: https://docs.google.com/document/d/1tL9Q95uf8FxhqS3vOTxCMz5lrMx6a7YG601VU61kqG8/edit?usp=sharing

After attending the lecture, or viewing the recording. Please reflect upon what you learned and follow the directions below. This assignment has two parts; reflections and goals. The goals section has two subparts: 3P goals and clinical goals. They do not need to be in APA format. But please choose a format that is organized and visually pleasing. You are not limited to a word document; PDF and PPT are acceptable. Please ensure your instructor is able to open your chosen media if not PDF, Word, or PPT. This should be your original work. Unique to you. Please work individually and do not collaborate with others on this reflective and personal goal-forming work.

· Reflection: 150-250 words

o Reflect upon what was learned and briefly write about your thoughts. Include:

§ What were you surprised to learn from the lecture, or what was new? If no material was new to you. What do you wish was covered instead?

§ Considering your own unique work-life-school situation. What are your greatest concerns or greater perceived challenges for the second half of the FNP program?

· Goals: (Separate from the above 250 word count)

o Considering your own personal situation and life challenges. Provide three specific goals to help guide your success in two areas

o Goals for the 3P courses: (three goals, bullet points are acceptable). For clinical experiences: (three goals, bullet points are acceptable)

· When writing your goals, try to keep in mind principles of SMART goals. (Specific, measurable, attainable, relevant/realistic, and time-oriented)

Some Examples: (but remember you need 3 of each goal type)

1)  My first 3P goal is to study pathophysiology for 6 hours every week. B setting aside 60 min every night from 8-8:30 for six nights a week.

2)  My first clinical goal is to contact 7 different clinics each week to look for a pediatric preceptor until I have found someone.

3)  My second clinical goal is to decrease my work to part-time. So that I can do 40 extra hours in my pediatric rotation in October-December 2022 so that I can be more marketable in a pediatric practice after graduation.

 

 

Issues And Trends In Nursing

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Issues And Trends In Nursing

Instructions: Reflect on any ONE of the following issues and post your answer on the discussion forum. Student must respond to at least two other students:

1. How do you think nursing education has changed in the past 100 years?

2. What are the pertinent societal trends and issues that affect nursing education?

3. How has the information explosion  affected nursing education?

4. What ethical concerns have emerged that require changes in nursing education?

5. How will you cope with high stress levels of increasing professional and personal responsibilities?

Posts should be no less than 250 words and each student is to respond to at least two other students in the class. Responses should be no less than 100 words in length

create a personal FlexPath Prep Plan

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For this assessment, you will create a personal FlexPath Prep Plan.

Remember that this plan is truly for you. Creating it will help you:

· Recognize the knowledge, skills, and strengths you bring to your FlexPath experience.

· Think about what you may need to change to succeed in FlexPath.

· Create a realistic plan for fitting FlexPath course work into your life.

· Prepare for your first meeting with your FlexPath coach.

· Begin your first academic course feeling prepared.

For each question below, think about what you know about yourself and consider what you have learned in orientation. Use this document and fill in the spaces. Answer each question as completely as possible, using complete sentences. You should be able to write at least 3–4 well-constructed sentences for each bullet point.

· Now that you have been through FlexPath orientation, what seems new and different about the FlexPath model, and what adjustments will you need to make to be successful in this model?

Are there things about the FlexPath model that may be a challenge for you, or that make you apprehensive?

 

 

Write your     response here.

· How will you schedule time in your already-busy life to complete the assessments and be successful in FlexPath?

What things might possibly interfere with your schedule and how will you address them?

 

 

Write your response here.

 

· What skills, knowledge, and strengths do you feel you bring to the FlexPath program?

How can use your skills, knowledge, and strengths to be successful in FlexPath?

Assessing And Treating Pediatric Patients With Mood Disorders

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5 REFERENCE NOT MORE THAN 5 YEARS/APA 7 WRITING STYLE/FORMAT

When pediatric patients present with mood disorders, the process of assessing, diagnosing, and treating them can be quite complex. Children not only present with different signs and symptoms than adult patients with the same disorders, they also metabolize medications much differently. Yet, there may be times when the same psychopharmacologic treatments may be used in both pediatric and adult cases with major depressive disorders. As a result, psychiatric nurse practitioners must exercise caution when prescribing psychotropic medications to these patients. For this Assignment, as you examine the patient case study in this week’s Learning Resources, consider how you might assess and treat pediatric patients presenting with mood disorders.

To prepare for this Assignment:

  • Review this week’s Learning Resources, including the Medication Resources indicated for this week.
  • Reflect on the psychopharmacologic treatments you might recommend for the assessment and treatment of pediatric patients requiring antidepressant therapy.

The Assignment: 5 pages

Examine Case Study: An African American Child Suffering From Depression. You will be asked to make three decisions concerning the medication to prescribe to this patient. Be sure to consider factors that might impact the patient’s pharmacokinetic and pharmacodynamic processes.

At each decision point, you should evaluate all options before selecting your decision and moving throughout the exercise. Before you make your decision, make sure that you have researched each option and that you evaluate the decision that you will select. Be sure to research each option using the primary literature.

Introduction to the case (1 page)

  • Briefly explain and summarize the case for this Assignment. Be sure to include the specific patient factors that may impact your decision making when prescribing medication for this patient.

Decision #1 (1 page)

  • Which decision did you select?
  • Why did you select this decision? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • Why did you not select the other two options provided in the exercise? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources (including the primary literature).
  • Explain how ethical considerations may impact your treatment plan and communication with patients. Be specific and provide examples.

Decision #2 (1 page)

  • Why did you select this decision? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • Why did you not select the other two options provided in the exercise? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources (including the primary literature).
  • Explain how ethical considerations may impact your treatment plan and communication with patients. Be specific and provide examples.

Decision #3 (1 page)

  • Why did you select this decision? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • Why did you not select the other two options provided in the exercise? Be specific and support your response with clinically relevant and patient-specific resources, including the primary literature.
  • What were you hoping to achieve by making this decision? Support your response with evidence and references to the Learning Resources (including the primary literature).
  • Explain how ethical considerations may impact your treatment plan and communication with patients. Be specific and provide examples.

Conclusion (1 page)

Maryland Spice company.

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Comprise a 5-6 page paper (excluding the title page and reference list page) that includes ALL of the following points:

  • 3 scholarly references/sources from our UMGC library. These should be current, preferably in the past 5 years. articles should be published within the past five years. If you cannot find precisely what you seek, then search for ten years out. However, anything older than this will be dated and not capturing the realities faced by today’s organizations.
  • Follow APA style guidelines to ensure that your final submission includes a Title Page, In-Text Citations, and a Reference List.

Charles Jackson is chief information officer (CIO) at McConnell Spice, a large Maryland Spice company. In an industry that has a large national market presence yet is global in its need for raw materials. McConnell Spice is always looking for ways to increase productivity. And speed things up while staying connected to its worldwide sources. Two years into the job, Jackson suggested to company president Ann McConnell that McConnell implement a new global knowledge-sharing application. That promises to cut development time and costs in half. Jackson has done extensive research on knowledge-sharing systems. And has talked closely with a fellow IT director at the global powerhouse ADM. The ADM director believes the knowledge-sharing systems play an important role in a company’s competitiveness. And concurs that Jackson should pursue purchasing one.

McConnell presented the idea to the board of directors, and everyone agreed to pursue the project. She has asked Jackson to investigate firms that could assist McConnell’s IT department in developing. And implementing a global knowledge-sharing application that would be compatible with McConnell’s existing systems. McConnell explained that she wants to present the information to the board of directors for a decision next month.

major firms

Jackson and his team, after many long nights, identified three major firms that he believed could handle the work and made an appointment with McConnell to go over the findings. At the appointed time, Jackson approached McConnell’s office door, where he was immediately greeted by Geraldine Fox, a woman who served as a sort of executive assistant to McConnell. Fox took the information from Jackson and promised the president would review it within two days. Disappointed with being unable to submit the findings in person, Jackson returned to his team, who was anxiously awaiting Mc Connell’s response. Frustrated with the lack of feedback, Jackson sent the team home early to put salve on the wound. 

The next afternoon, McConnell called Jackson to her office and asked why Standard Systems, a small local consulting firm, was not being considered as a potential provider. Jackson was surprised—Standard was known primarily for helping small companies computerize their accounting systems. Jackson was not aware that they had done any work related to knowledge-sharing applications, particularly on a global basis. Upon further investigation into the company, Jackson learned that Standard was owned by an uncle of McConnell’s son-in-law. Fortunately, he also learned that the firm had some limited experience in more complex applications. At their most recent meeting, McConnell insisted that Standard be included for possible consideration by the board.

major firms

During the next two weeks, representatives from each company met with Jackson, his two top executives, and the IT staff to explain their services and give demonstrations. Jackson had suggested that the board of directors attend these presentations, but McConnell said they would not have the time and he, Jackson, would need to evaluate everything and make a recommendation to the board. At the end of these meetings, Jackson prepared a final report evaluating the pros and cons of going with each firm and making his first- and second-choice recommendations. Standard was dead last on his list. Although the firm had some excellent people and a good reputation, it was simply not capable of handling such a large and complex project.

McConnell informed Jackson that the Board would meet in one week and he was to present his findings and decision to the Board for approval. McConnell said, “I know you agree with me and are for Standard, but we have to pretend that these other companies are in contention.” McConnell winks and walks away leaving Jackson devastated and appalled at the idea that the least effective company could get the job.

The Nursing Process In Practice

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The Nursing Process in Practice

Formulating a Family Care Plan

Mr. R., an 80-year-old retired pipe fitter, lives with his wife; he has had diabetes for 15 years. Although his diabetes has been moderately controlled with diet and daily insulin, some complications have occurred. He experiences arteriosclerotic cardiovascular disease and peripheral neuropathy, and he recently spent 2 months in the hospital due to circulatory problems in his left leg. The progressive deterioration of circulation resulted in an amputation below the knee. Although fitting him with a prosthesis would be possible, he has refused this and is wheelchair bound. Mr. R. currently depends on someone else to help with transfers. He is cranky, irritable, and demanding to almost everyone. He recently has stopped following his diabetes regimen because he claims, “It just doesn’t matter anymore.”

Mr. R.’s wife, Doris, is a 74-year-old woman who has been a homemaker most of her life. She has always been the “watchdog” for Mr. R.’s health. Mostly through her changes in food preparation and her lifestyle adjustments, Mr. R.’s diabetes has been managed. She schedules his physician appointments, buys his medical supplies, and administers his insulin. He is now refusing to accept her help, and she is anxious and angry about his behavior. They frequently have arguments, after which Mrs. R. retreats to her room.

Formulating a Family Care Plan

Mr. and Mrs. R. have three children and four grandchildren who live in the same city. The eldest daughter, Patricia, calls or stops by about once a week. The other children, Tom and Ellen, are busy with their families and see their parents mostly on holidays; they have very little communication with Patricia or their parents. When the children do come to visit, Doris tries to put on a happy expression and pretend that everything is going well to avoid worrying them. She is also embarrassed about Mr. R.’s behavior and does not want anyone from outside the family to see what is happening.

On her initial home visit to this family, the community health nurse notes that Mr. R. appears somewhat drowsy and unkempt. Mrs. R. looks anxious and tired, her skin color is slightly ashen, and she has circles under her eyes. When the nurse asks them what they hope to get out of the nursing visits, Mrs. R. says, “Actually, you don’t need to keep visiting. In a few weeks we’ll be back to normal and doing fine.”

Based on a thorough assessment of the family, the community health nurse may begin to develop a mutually acceptable plan of care with the family.

Assessment

In the initial interview, the community health nurse completes a genogram and an eco-map with the family (see  Figures 13-3  and  13-4 ). After the second family interview, the nurse also completes a family map that describes the members’ interactions with each other (see  Figure 13-2 ). A family guide to help structure a family assessment is presented in  Box 13-7 .

Completing the genogram helps break the ice to get the family to talk about their situation. The genogram provides a safe and thought-provoking way for Mrs. R. to supply appropriate information about the situation. During this process, the nurse obtains information about other family members, their general levels of functioning, and the possibility of acting as resources. She identifies family members’ patterns of closeness and distance.

 

 

Principles Of Organizational Behavior

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Principles Of Organizational Behavior

Imagine you work for a successful company and have been asked to be a guest speaker. For an entry-level organizational behavior course at a local college. The goal of your presentation is to help the college students gain a basic understanding of organizational behavior. And be able to speak to its importance in an organization.

Create a 350- to 700-word handout, such as a chart or a fact sheet. You can give to students during your presentation. Address the following in your handout:

  • Define organizational behavior.  
  • Describe how different components of organizational behavior are used within an organization.
  • Identify how the use of organizational behavior can lead to the success and failure of an organization.

Cite any reputable references. Reputable references include trade or industry publications; government or agency websites. Scholarly works; your textbook, Organizational Behavior in Health Care (4th ed.); or other sources of similar quality.

Format your references according to APA guidelines.